Osteoarthritis Research Today is a free monthly online journal that collates and summarizes the latest research about Osteoarthritis, including details on treatment, symptoms, causes, medication.

Mitochondrial DNA haplogroups and serum levels of proteolytic enzymes in patients with osteoarthritis.

Rego-Pérez I, Fernández-Moreno M, Deberg M, Pértega S, Fernández-López C, Oreiro N, Henrotin Y, Blanco FJ

Osteoarticular and Aging Research Laboratory, Biomedical Research Center, Complejo Hospitalario Universitario A Coruña, 15006-A Coruña, Spain.

Published 4 March 2011 in Ann Rheum Dis, 70(4): 646-52.
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Articles on Osteoarthritis published 4 March 2011:

Mitochondrial DNA haplogroups and serum levels of proteolytic enzymes in patients with osteoarthritis.   Ann Rheum Dis, 70(4): 646-52.

[Abstract] [Full-text]

Factors influencing health-related quality of life after TKA in patients who are obese.   Clin Orthop Relat Res, 469(4): 1148-53.

[Abstract] [Full-text]

The need for total hip arthroplasty in Perthes disease: a long-term study.   Clin Orthop Relat Res, 469(4): 1134-40.

[Abstract] [Full-text]

Articles on Osteoarthritis published 1 March 2011:

Relationships of hip joint volume ratios with degrees of joint laxity and degenerative disease from youth to maturity in a canine population predisposed to hip joint osteoarthritis.   Am J Vet Res, 72(3): 376-83.

[Abstract] [Full-text]

Articles on Osteoarthritis published 28 February 2011:

Cross-sectional study of the prevalence and clinical features of osteoarthritis in 100 cats.   Vet J, 187(3): 304-9.

To assess clinical signs and relevance of osteoarthritis (OA) in cats, the radiographic prevalence of OA in the appendicular skeleton of 100 client-owned cats (≥ 6 years old) was assessed. Possible associations between radiographic OA, clinical locomotor system examination, and owner-perceived behavioural changes were evaluated. OA was most prevalent in the shoulders, elbows, hips and tarsal joints with 61% of cats having OA in at least one joint and 48% in more than one joint. Overall, ... [Abstract] [Full-text]

Articles on Osteoarthritis published 21 February 2011:

Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.   J Orthop Res, 29(4): 516-22.

To investigate the role of ADAMTS5 in murine osteoarthritis (OA), resulting from destabilization of the medial meniscus (DMM model) or from TGFb1 injection and enforced uphill treadmill running (TTR model). Wild-type (WT) and ADAMTS5-/- mice were subjected to either DMM or TTR and joints were evaluated for meniscal damage, cartilage changes, and fibrotic ingrowths from the joint margins. Cartilage lesions were quantified on an 8-point scoring system. Cartilage chondroitin sulfate (CS) content ... [Abstract] [Full-text]

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions.   J Orthop Res, 29(4): 511-5.

SIRT1 has been implicated as a key factor in aging-related diseases. Nevertheless, the role of SIRT1 in the pathogenesis of osteoarthritis (OA) is still unknown. We examined the expression of SIRT1 in cartilage samples and the effect of SIRT1 inhibition on chondrocyte gene expression changes to elucidate the role of SIRT1 in chondrocytes. SIRT1 expression was examined using cartilage samples from patients undergoing total knee arthroplasty and femoral head replacement by immunohistochemistry. ... [Abstract] [Full-text]

Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.   J Orthop Res, 29(4): 516-22.

To investigate the role of ADAMTS5 in murine osteoarthritis (OA), resulting from destabilization of the medial meniscus (DMM model) or from TGFb1 injection and enforced uphill treadmill running (TTR model). Wild-type (WT) and ADAMTS5-/- mice were subjected to either DMM or TTR and joints were evaluated for meniscal damage, cartilage changes, and fibrotic ingrowths from the joint margins. Cartilage lesions were quantified on an 8-point scoring system. Cartilage chondroitin sulfate (CS) content ... [Abstract] [Full-text]

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